NONO, A NON-POU-DOMAIN-CONTAINING, OCTAMER-BINDING PROTEIN, IS THE MAMMALIAN HOMOLOG OF DROSOPHILA-NONADISS

被引:102
作者
YANG, YS
HANKE, JH
CARAYANNOPOULOS, L
CRAFT, CM
CAPRA, JD
TUCKER, PW
机构
[1] UNIV TEXAS, SW MED CTR, DEPT MICROBIOL, 5323 HARRY HINES BLVD, DALLAS, TX 75235 USA
[2] UNIV TEXAS, SW MED CTR, DEPT PSYCHIAT, DALLAS, TX 75235 USA
关键词
D O I
10.1128/MCB.13.9.5593
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have cloned the ubiquitous form of an octamer-binding, 60-kDa protein (NonO) that appears to be the mammalian equivalent of the Drosophila visual and courtship song behavior protein, no-on-transient A/dissonance (nonA(diss)). A region unprecedently rich in aromatic amino acids containing two ribonuclear protein binding motifs is highly conserved between the two proteins. A ubiquitous form of NonO is present in all adult tissues, whereas lymphocytes and retina express unique forms of NonO mRNA. The ubiquitous form contains a potential helix-turn-helix motif followed by a highly charged region but differs from prototypic octamer-binding factors by lacking the POU DNA-binding domain. In addition to its conventional octamer duplex-binding, NonO binds single-stranded DNA and RNA at a site independent of the duplex site.
引用
收藏
页码:5593 / 5603
页数:11
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