CARDIOVASCULAR EFFECTS OF LITHIUM IN MAN - REVIEW OF LITERATURE

被引:77
作者
TILKIAN, AG
SCHROEDER, JS
KAO, JJ
HULTGREN, HN
机构
[1] VET ADM HOSP, PALO ALTO, CA 94305 USA
[2] STANFORD UNIV, SCH MED, DIV PSYCHIAT, STANFORD, CA 94305 USA
[3] STANFORD UNIV, SCH MED, DIV CARDIOL, STANFORD, CA 94305 USA
关键词
D O I
10.1016/0002-9343(76)90145-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The medical literature since 1900 was reviewed to determine the nature of cardiovascular effects of Li. In therapeutic doses, Li produces reversible T wave flattening and inversion in the ECG; rarely, it may cause sinus node dysfunction or ventricular arrhythmias. Patients with Li toxicity almost always present with neurologic signs and symptoms. Hypotension and cardiovascular collapse, alleged cardiotoxic manifestations of Li, invariably follow days of coma. Given the possible cardiotoxic effect of other psychopharmacologic agents and the hazards of withholding effect therapy in mania, Li may be used safely in patients with cardiac disease if the dose is adjusted to the rate of Li excretion and if serum Li levels are followed carefully. When used in patients with cardiac arrhythmias, frequent ECG monitoring is advised.
引用
收藏
页码:665 / 670
页数:6
相关论文
共 66 条
[1]  
ALLGEN LG, 1969, ACTA PSYCHIAT S S207, P98
[2]   SUDDEN DEATH AND ISCHEMIC HEART DISEASE - CORRELATION WITH HARDNESS OF LOCAL WATER SUPPLY [J].
ANDERSON, TW ;
LERICHE, WH ;
MACKAY, JS .
NEW ENGLAND JOURNAL OF MEDICINE, 1969, 280 (15) :805-&
[3]  
ANDREANI G, 1957, G Clin Med, V38, P1759
[4]  
AOKI FY, 1971, CAN MED ASSOC J, V105, P847
[5]   LITHIUM SALTS - 1970-1975 [J].
BALDESSARINI, RJ ;
LIPINSKI, JF .
ANNALS OF INTERNAL MEDICINE, 1975, 83 (04) :527-533
[6]  
BALDESSARINI RJ, 1970, ARCH GEN PSYCHIAT, V22, P72
[7]   DISTRIBUTION OF LITHIUM AND ITS EFFECTS ON DISTRIBUTION AND EXCRETION OF OTHER IONS IN RAT [J].
BIRCH, NJ ;
JENNER, FA .
BRITISH JOURNAL OF PHARMACOLOGY, 1973, 47 (03) :586-594
[8]  
BOULETREAU P, 1974, B MED LEG TOX MED, V17, P385
[9]  
BROWN WT, 1973, CAN MED ASSOC J, V108, P742
[10]   LITHIUM SALTS IN THE TREATMENT OF PSYCHOTIC EXCITEMENT [J].
CADE, JFJ .
MEDICAL JOURNAL OF AUSTRALIA, 1949, 2 (10) :349-352