MAPPING OF MOUSE CARBONIC ANHYDRASE-3, CAR-3 - ANOTHER LOCUS IN THE HOMOLOGOUS REGION OF MOUSE CHROMOSOME-3 AND HUMAN CHROMOSOME-8

被引:15
作者
BEECHEY, C
TWEEDIE, S
SPURR, N
BALL, S
PETERS, J
EDWARDS, Y
机构
[1] MRC,DIV GENET,RADIOBIOL UNIT,DIDCOT OX11 ORD,OXON,ENGLAND
[2] UNIV LONDON UNIV COLL,GALTON LAB,MRC,HUMAN BIOCHEM GENET UNIT,LONDON NW1 2HE,ENGLAND
[3] IMPERIAL CANC RES FUND,CLARE HALL LABS,S MIMMS EN6 3LD,HERTS,ENGLAND
关键词
D O I
10.1016/0888-7543(90)90506-P
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
At least six separate genes determining tissue- and organelle-specific isoforms of carbonic anhydrase are known. We have determined the chromosome location of one of these genes, carbonic anhydrase-3 (Car-3), in the mouse and carried out a linkage analysis of Car-1, Car-2, and Car-3. Car-3 has been assigned to band 3A2 by in situ hybridization. We identified a PstI restriction fragment length polymorphism between Mus spretus and Mus mus domesticus and, by using an interspecific backcross, showed that Car-3 is 2.4 ± 1.7% SE from both Car-1 and Car-2, calculating genetic distance as percentage recombination. No recombinants were found between Car-1 and Car-2 in 100 backcross offspring, and when these data are combined with earlier results, these two loci are estimated to be 1.2 cM from each other at the 95% confidence interval. The three homologous carbonic anhydrase loci in man had earlier been assigned to 8q22, and the finding of linkage of Car-3 to Car-1 and Car-2 in the mouse adds another locus to the conserved segments on mouse chromosome 3 and human chromosome 8. © 1990.
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页码:692 / 696
页数:5
相关论文
共 23 条
  • [1] MAPPING OF THE ONCOGENES MYC, SIS, AND INT-1 TO THE DISTAL PART OF MOUSE CHROMOSOME-15
    ADOLPH, S
    BARTRAM, CR
    HAMEISTER, H
    [J]. CYTOGENETICS AND CELL GENETICS, 1987, 44 (2-3): : 65 - 68
  • [2] CARTER ND, 1972, COMP BIOCH PHYSL, V438, P743
  • [3] THE NUCLEOTIDE-SEQUENCE AND DERIVED AMINO-ACID-SEQUENCE OF CDNA CODING FOR MOUSE CARBONIC ANHYDRASE-II
    CURTIS, PJ
    WITHERS, E
    DEMUTH, D
    WATT, R
    VENTA, PJ
    TASHIAN, RE
    [J]. GENE, 1983, 25 (2-3) : 325 - 332
  • [4] REGIONAL LOCALIZATION OF CARBONIC-ANHYDRASE GENES CA1 AND CA3 ON HUMAN CHROMOSOME-8
    DAVIS, MB
    WEST, LF
    BARLOW, JH
    BUTTERWORTH, PHW
    LLOYD, JC
    EDWARDS, YH
    [J]. SOMATIC CELL AND MOLECULAR GENETICS, 1987, 13 (02) : 173 - 178
  • [5] EVIDENCE FOR LINKAGE OF CARBONIC-ANHYDRASE ISOENZYME GENES IN PIG-TAILED MACAQUE, MACACA-NEMESTRINA
    DESIMONE, J
    LINDE, M
    TASHIAN, RE
    [J]. NATURE-NEW BIOLOGY, 1973, 242 (115): : 55 - 56
  • [6] THE GENE FOR HUMAN-MUSCLE SPECIFIC CARBONIC-ANHYDRASE (CAIII) IS ASSIGNED TO CHROMOSOME-8
    EDWARDS, YH
    LLOYD, J
    PARKAR, M
    POVEY, S
    [J]. ANNALS OF HUMAN GENETICS, 1986, 50 : 41 - 47
  • [7] ASSIGNMENT OF THE GENE DETERMINING HUMAN CARBONIC-ANHYDRASE, CAI, TO CHROMOSOME-8
    EDWARDS, YH
    BARLOW, JH
    KONIALIS, CP
    POVEY, S
    BUTTERWORTH, PHW
    [J]. ANNALS OF HUMAN GENETICS, 1986, 50 : 123 - 129
  • [8] EVOLUTION OF MAMMALIAN CARBONIC-ANHYDRASE LOCI BY TANDEM DUPLICATION - CLOSE LINKAGE OF CAR-1 AND CAR-2 TO CENTROMERE REGION OF CHROMOSOME-3 OF MOUSE
    EICHER, EM
    STERN, RH
    WOMACK, JE
    DAVISSON, MT
    RODERICK, TH
    REYNOLDS, SC
    [J]. BIOCHEMICAL GENETICS, 1976, 14 (7-8) : 651 - 660
  • [9] NON-CYTOPLASMIC CARBONIC-ANHYDRASES
    FERNLEY, RT
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 1988, 13 (09) : 356 - 359
  • [10] Ford CE, 1966, TISSUE GRAFTING RADI, P197