ISOLATION OF VGR-2, A NOVEL MEMBER OF THE TRANSFORMING GROWTH FACTOR-BETA-RELATED GENE FAMILY

被引：54

作者：

JONES, CM ^{[1
]}

SIMONCHAZOTTES, D ^{[1
]}

GUENET, JL ^{[1
]}

HOGAN, BLM ^{[1
]}

机构：

[1] INST PASTEUR,DEPT IMMUNOL,F-75724 PARIS 15,FRANCE

来源：

MOLECULAR ENDOCRINOLOGY | 1992年 / 6卷 / 11期

关键词：

D O I：

10.1210/me.6.11.1961

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A cDNA clone, Vgr-2, with homology to certain members of the transforming growth factor-beta superfamily has been isolated from a mouse embryo cDNA library. The encoded protein shows significant similarity to members of the Vg-1/decapentaplegic/bone morphogenetic protein subgroup of the transforming growth factor-beta family. Within this group, Vgr-2 is more similar to Xenopus Vg-1 than to any other member so far isolated. The gene is expressed at highest levels during midgestation mouse development, and transcripts are localized by in situ hybridization to the osteogenic zone of developing bone. Vgr-2 is expressed in F9 teratocarcinoma cells, and its RNA levels are down-regulated within 24 h after differentiation with retinoic acid. The genomic organization of Vgr-2 and Its location on mouse chromosome 6 are reported.

引用

页码：1961 / 1968

页数：8

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