REVERSAL OF CHANGES IN LEFT-VENTRICULAR DIASTOLIC FILLING ASSOCIATED WITH NORMAL AGING USING DILTIAZEM

被引：21

作者：

MANNING, WJ

SHANNON, RP

SANTINGA, JA

PARKER, JA

GERVINO, EV

COME, PC

WEI, JY

机构：

[1] BETH ISRAEL HOSP,HARVARD THORNDIKE LAB,BOSTON,MA 02215

[2] BETH ISRAEL HOSP,DEPT MED,DIV CARDIOVASC,BOSTON,MA 02215

[3] BETH ISRAEL HOSP,DEPT MED,DIV GERONTOL,BOSTON,MA 02215

[4] BETH ISRAEL HOSP,DEPT RADIOL,BOSTON,MA 02215

[5] HARVARD UNIV,SCH MED,BOSTON,MA 02115

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1991年 / 67卷 / 09期

关键词：

D O I：

10.1016/0002-9149(91)90628-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Congestive heart failure is a common problem in clinical geriatrics and often the result of diastolic rather than systolic dysfunction.1 Normal aging is associated with a reduction in the rate of calcium ion uptake by the sarcoplasmic reticulum.2 Because intracellular handling of calcium may affect isovolumic relaxation and left ventricular (LV) compliance, a calcium antagonist may be beneficial. The pattern of LV diastolic filling may be accurately characterized by both pulsed Doppler transmitral flow velocities3 and radionuclide scintigraphy.4 The present study tests the hypothesis that a calcium antagonist, diltiazem, may be effective in reversing the impairment of early diastolic LV filling seen in elderly subjects. © 1991.

引用

收藏

页码：894 / 896

页数：3

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