PHASE-II STUDY OF FOTEMUSTINE IN UNTREATED INOPERABLE NON-SMALL-CELL LUNG-CANCER

被引：3

作者：

RUDD, R

ALLEN, R

BERILLE, J

SPIRO, SG

TRASK, C

SOUHAMI, RL

机构：

[1] UCL, MIDDLESEX HOSP, SCH MED, DEPT ONCOL, LONDON W1N 8AA, ENGLAND

[2] UCL, MIDDLESEX HOSP, SCH MED, DEPT RESP MED, LONDON W1N 8AA, ENGLAND

[3] LONDON CHEST HOSP, LONDON E2 9JX, ENGLAND

[4] INST RECH INT SERVIER, DIV THERAPEUT CANCEROL, F-92415 COURBEVOIE, FRANCE

[5] SOUTHMEAD GEN HOSP, DEPT RADIOTHERAPY, WESTCLIFF ON SEA SS0 0RY, ESSEX, ENGLAND

来源：

CANCER CHEMOTHERAPY AND PHARMACOLOGY | 1994年 / 34卷 / 05期

关键词：

LUNG CANCER; CHEMOTHERAPY; FOTEMUSTINE; PHASE II;

D O I：

10.1007/BF00685572

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A total of 43 patients with advanced, previously untreated non-small-cell lung cancer (NSCLC) were treated with a novel nitrosourea, fotemustine, given at 100 mg/m(2) on days 1 and 8. Maintenance treatment consisted of a single injection of 100 mg/m(2) given every 21 days. 37 patients were evaluable for respone. Of these, 5 patients had a partial response (13.5%; 95% confidence interval, 6%-28%). Toxicity comprised mainly anaemia and thrombocytopenia. Other toxicities were mild. This phase II study confirms that fotemustine is a moderately active and well-tolerated drug in NSCLC.

引用

页码：444 / 446

页数：3

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