IGG SUBCLASS ANTIBODY-RESPONSES TO PNEUMOCOCCAL POLYSACCHARIDE VACCINE IN SPLENECTOMIZED, OTHERWISE NORMAL, INDIVIDUALS

被引：16

作者：

AABERGE, IS

MICHAELSEN, TE

HEIER, HE

机构：

[1] National Institute of Public Health, Department of Immunology, Oslo

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1990年 / 31卷 / 06期

关键词：

D O I：

10.1111/j.1365-3083.1990.tb02822.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Subclasses of IgG antibodies to pneumococcal polysaccharide serotypc antigens 4, 6A. and 23F were measured before and 4 weeks after vaccination with pneumoeoccal vaccine in young individuals splencetomized because of trautna and in a control group. An ELISA technique was applied. IgG2 anti‐pneuniococcal antibodies predominated before vaccination, especially against serotypes 4 anti 6A. The youngest individuals in the splenectomy group tended to have lower IgG2 antl‐pneumococcal antibody levels than the older ones. Vaccination induced antibodies of the IgGl and IgG2 subclasses, and in sotne individuals also of the IgG4 subclass. Splencetomy does not seem to inffuence the IgG subcllass paltern of antipneuniococcal antibodies. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：711 / 716

页数：6

共 30 条

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