COMPLETION OF THE LAST HALF OF THE STRUCTURE OF THE HUMAN GENE FOR THE PRO-ALPHA-1(I) CHAIN OF TYPE-I PROCOLLAGEN (COL1A1)

被引：19

作者：

WESTERHAUSEN, A ^{[1
]}

CONSTANTINOU, CD ^{[1
]}

PACK, M ^{[1
]}

PENG, M ^{[1
]}

HANNING, C ^{[1
]}

OLSEN, AS ^{[1
]}

PROCKOP, DJ ^{[1
]}

机构：

[1] THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,JEFFERSON INST MOLEC MED,DEPT BIOCHEM & MOLEC BIOL,PHILADELPHIA,PA 19107

来源：

MATRIX | 1991年 / 11卷 / 06期

关键词：

PROCOLLAGEN GENE; SEQUENCES OF INTRONS;

D O I：

10.1016/S0934-8832(11)80191-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nucleotide sequences of the 3'-half of the human gene for the proc-alpha(I) chain of type I procollagen (COL1A1) is presented. The results provide the nucleotide sequences for 26 introns not previously analyzed. The sequences that are presented, together with those previously published, make it possible to design primers for the polymerase chain reaction for amplifying and sequencing the gene. The availability of such primers will greatly facilitate the current search for mutations that can cause common and rare diseases of connective tissue.

引用

页码：375 / 379

页数：5

共 17 条

[1]

BARSH GS, 1984, J BIOL CHEM, V259, P4906

[2] INTRON-MEDIATED RECOMBINATION MAY CAUSE A DELETION IN AN ALPHA-1 TYPE-I COLLAGEN CHAIN IN A LETHAL FORM OF OSTEOGENESIS IMPERFECTA [J].