PHENOTYPIC AND CYTOGENETIC STUDIES IN SELF-POISONED PATIENTS

被引：15

作者：

CZEIZEL, AE

机构：

[1] Department of Human Genetics and Teratology, National Institute, Hygiene-WHO Collaborating Centre for the Community Control of Hereditary Diseases, Budapest

来源：

MUTATION RESEARCH-ENVIRONMENTAL MUTAGENESIS AND RELATED SUBJECTS | 1994年 / 313卷 / 2-3期

关键词：

SELF-POISONER; PHENOTYPIC STUDY; MUTAGENESIS EPIDEMIOLOGY; CYTOGENETIC STUDY; TRICHLORFON; DIAZEPAM; INTRAUTERINE GROWTH RETARDATION;

D O I：

10.1016/0165-1161(94)90047-7

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Persons who attempt suicide by taking high doses of chemicals but survive may represent an appropriate human model of mutagenesis epidemiology for the study of somatic and germinal mutagenicity of drugs, pesticides and other chemicals. The most important results of systematic studies in self-poisoning individuals over the last 20 years are summarized. Trichlorfon and diazepam caused a higher rate of aneuploidy in peripheral lymphocytes. The frequency of chromatid aberrations was lower in self-poisoned pregnant women than in self-poisoned non-pregnant women and these findings suggest a possible protective effect of pregnancy. Intrauterine growth retardation was found in children born after self-poisoning.

引用

页码：175 / 181

页数：7

共 24 条

[1]

BAO T, 1922, MUTAT RES, V298, P131

[2]

BAO T, 1974, HUMANGENETIK, V24, P33

[3] LACK OF EFFECT OF SELF-POISONING ON SUBSEQUENT REPRODUCTIVE OUTCOME [J].

CZEIZEL, A ;

SZENTESI, I ;

MOLNAR, G .

MUTATION RESEARCH, 1984, 127 (02) :175-182

[4] A STUDY OF ADVERSE-EFFECTS ON THE PROGENY AFTER INTOXICATION DURING PREGNANCY [J].

CZEIZEL, A ;

SZENTESI, I ;

SZEKERES, I ;

MOLNAR, G ;

GLAUBER, A ;

BUCSKI, P .

ARCHIVES OF TOXICOLOGY, 1988, 62 (01) :1-7

[5] POPULATION SURVEILLANCE OF SENTINEL ANOMALIES [J].

CZEIZEL, A .

MUTATION RESEARCH, 1989, 212 (01) :3-9

[6]

CZEIZEL A, 1984, ACTA MED HUNG, V41, P77

[7]

CZEIZEL A, 1986, NEW CONCEPTS DEV TOX, P49

[8]

CZEIZEL A, 1988, ACTA MORPHOL HUNG, V36, P63

[9] LOWER BIRTH-WEIGHT OF OFFSPRING BORN AFTER SELF-POISONING OF PARENT [J].

CZEIZEL, AE ;

SZABADOS, A ;

SUSANSZKY, E .

MUTATION RESEARCH, 1992, 269 (01) :35-39

[10] INTRAUTERINE GROWTH-RETARDATION AS A POTENTIAL END-POINT IN MUTATION EPIDEMIOLOGY [J].

CZEIZEL, AE .

MUTATION RESEARCH, 1993, 296 (03) :211-219

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