CONFORMATIONAL ISOMERIZATIONS OF THE POLY(DA-DT) AND POLY(AMINO2DA-DT) DUPLEXES INVOLVING THE UNUSUAL X-DNA DOUBLE HELIX - A 4TH DERIVATIVE SPECTROPHOTOMETRIC STUDY

被引:6
作者
GARRIGA, P [1 ]
SAGI, J [1 ]
QUINTANA, DG [1 ]
SABES, M [1 ]
MANYOSA, J [1 ]
机构
[1] HUNGARIAN ACAD SCI, CENT RES INST CHEM, H-1525 BUDAPEST, HUNGARY
关键词
D O I
10.1080/07391102.1990.10508546
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Fourth derivative spectrophotometry has been applied to monitor conformational isomerizations of polynucleotides for the first time. The transitions studied have been the B-A and A-X isomerizations of poly(dA-dT) and the B-X one of poly(amino2dA-dT). Parameters obtained from the fourth derivative spectra have been used to follow these conformational changes. The A form of poly(dA-dT) has been characterized by a new fourth derivative peak at 293.0 nm which can be associated to interstrand adenine-adenine interactions. Furthermore, some of the fourth derivative peaks in the long wavelength region (270-310 nm) can be related to stacking interactions present in the polynucleotide double helices. The tentative assignment of these peaks, particularly that at 299.0 nm in the derivative spectra of poly(amino2dA-dT), to n→π* electronic transitions is discussed. © Taylor & Francis Group, LLC.
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页码:1061 / 1071
页数:11
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