TGF-ALPHA IS WIDELY EXPRESSED IN DIFFERENTIATED AS WELL AS HYPERPROLIFERATIVE SKIN EPITHELIUM

被引：54

作者：

FINZI, E ^{[1
]}

HARKINS, R ^{[1
]}

HORN, T ^{[1
]}

机构：

[1] TRITON BIOSCI INC,DEPT PROT BIOCHEM,ALAMEDA,CA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1991年 / 96卷 / 03期

关键词：

D O I：

10.1111/1523-1747.ep12465223

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Transforming growth factor-alpha (TGF-alpha) is a potent mitogen for epithelial cells that is expressed at low levels in normal epidermis and overexpressed in psoriasis. Epidermal growth factor (EGF) has been shown to inhibit hair growth but stimulate the growth of sebaceous and sweat glands, suggesting a potential role for a member of the EGF/TGF-alpha family in the normal development and function of skin appendages as well as epidermis. The present work demonstrates TGF-alpha protein in eccrine ducts, and eccrine, sebaceous, and apocrine glands. The proliferative dermal hair bulb does not express TGF-alpha in contrast to the differentiated outer root sheath hair follicle epithelia. In addition, hyperproliferative skin diseases including bullous congenital ichthyosiform erythroderma, squamous cell carcinoma, and psoriasis show increased TGF-alpha expression. Thus, TGF-alpha may play a role in the morphogenesis and function of normal skin appendages and its over-expression is common in benign and malignant hyperproliferative skin diseases.

引用

页码：328 / 332

页数：5

共 42 条

[1] CELL-CELL ADHESION MEDIATED BY BINDING OF MEMBRANE-ANCHORED TRANSFORMING GROWTH FACTOR-ALPHA TO EPIDERMAL GROWTH-FACTOR RECEPTORS PROMOTES CELL-PROLIFERATION
ANKLESARIA, P
TEIXIDO, J
LAIHO, M
PIERCE, JH
GREENBERGER, JS
MASSAGUE, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (09) : 3289 - 3293
[2] INDUCTION OF SWEAT GLANDS BY EPIDERMAL GROWTH-FACTOR IN MURINE X-LINKED ANHIDROTIC ECTODERMAL DYSPLASIA
BLECHER, SR
KAPALANGA, J
LALONDE, D
[J]. NATURE, 1990, 345 (6275) : 542 - 544
[3] TRANSMEMBRANE TGF-ALPHA PRECURSORS ACTIVATE EGF TGF-ALPHA RECEPTORS
BRACHMANN, R
LINDQUIST, PB
NAGASHIMA, M
KOHR, W
LIPARI, T
NAPIER, M
DERYNCK, R
[J]. CELL, 1989, 56 (04) : 691 - 700
[4] DIFFERENT TRANSFORMING GROWTH FACTOR-ALPHA SPECIES ARE DERIVED FROM A GLYCOSYLATED AND PALMITOYLATED TRANSMEMBRANE PRECURSOR
BRINGMAN, TS
LINDQUIST, PB
DERYNCK, R
[J]. CELL, 1987, 48 (03) : 429 - 440
[5] ANTIBODIES TO THE EPIDERMAL GROWTH-FACTOR RECEPTOR BLOCK THE BIOLOGICAL-ACTIVITIES OF SARCOMA GROWTH-FACTOR
CARPENTER, G
STOSCHECK, CM
PRESTON, YA
DELARCO, JE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (18): : 5627 - 5630
[6] EPIDERMAL GROWTH-FACTOR REGULATES THE EXPRESSION OF ITS OWN RECEPTOR
CLARK, AJL
ISHII, S
RICHERT, N
MERLINO, GT
PASTAN, I
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (24) : 8374 - 8378
[7] COFFEY RJ, 1988, CANCER RES, V48, P1596
[8] PRODUCTION AND AUTOINDUCTION OF TRANSFORMING GROWTH FACTOR-ALPHA IN HUMAN KERATINOCYTES
COFFEY, RJ
DERYNCK, R
WILCOX, JN
BRINGMAN, TS
GOUSTIN, AS
MOSES, HL
PITTELKOW, MR
[J]. NATURE, 1987, 328 (6133) : 817 - 820
[9] TRANSFORMING GROWTH FACTOR-ALPHA
DERYNCK, R
[J]. CELL, 1988, 54 (05) : 593 - 595
[10] DERYNCK R, 1987, CANCER RES, V47, P707

← 1 2 3 4 5 →