MOLECULAR-CLONING AND CHROMOSOMAL ASSIGNMENT OF HUMAN CALBINDIN-D9K

被引：40

作者：

HOWARD, A

LEGON, S

SPURR, NK

WALTERS, JRF

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT MED,GASTROENTEROL UNIT,DUCANE RD,LONDON W12 0NN,ENGLAND

[2] IMPERIAL CANC RES FUND,CLARE HALL LABS,HUMAN GENET RESOURCES LAB,S MIMMS EN6 3LD,HERTS,ENGLAND

[3] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT CHEM PATHOL,LONDON W12 0NN,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 185卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0006-291X(92)91676-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human calbindin-D9k, the vitamin D-dependent calcium binding protein, has been cloned and sequenced following initial amplification of intestinal cDNA sequences by the polymerase chain reaction using mixed oligonucleotide primers. The derived amino acid sequence of 79 residues has a calculated molecular weight of 9015 and is 89% homologous with the bovine and porcine sequences. Probing DNA from human-rodent somatic cell hybrids mapped human calbindin-D9k to chromosome Xp. A single abundant mRNA transcript was detectable in proximal small intestine but not in kidney, uterus or placenta. © 1992.

引用

页码：663 / 669

页数：7

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