A CONCISE SYNTHESIS OF 12-(3'-HYDROXY-N-PROPYL)-DEOXOARTEMISININ

被引：41

作者：

JUNG, M

YU, D

BUSTOS, D

ELSOHLY, HN

MCCHESNEY, JD

机构：

[1] UNIV MISSISSIPPI, SCH PHARM, DEPT MED CHEM, UNIVERSITY, MS 38677 USA

[2] UNIV MISSISSIPPI, SCH PHARM, DEPT PHARMACOGNOSY, UNIVERSITY, MS 38677 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)81060-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 12-(3'-hydroxy-n-propyl)-deoxoartemisinin was synthesized from artemisinic acid via photooxidative cyclization as a key step. The title compound 6a is found to show five times greater in vitro antimalarial activity compared to artemisinin.

引用

页码：741 / 744

页数：4

共 12 条

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