NEW SYNTHESIS OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYNUCLEOSIDES

被引：7

作者：

ABDELMEGIED, AES

HANSEN, P

PEDERSEN, EB ^{[1
]}

NIELSEN, CM

机构：

[1] ODENSE UNIV,DEPT CHEM,DK-5230 ODENSE,DENMARK

[2] STATENS SERUMINST,DEPT ENTEROVIRUS,RETROVIRUS LAB,DK-2300 COPENHAGEN,DENMARK

来源：

ACTA CHEMICA SCANDINAVICA | 1991年 / 45卷 / 10期

关键词：

D O I：

10.3891/acta.chem.scand.45-1060

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 3'-iodonucleoside 4 and the 3'-O-methylsulfonylthymidine 9 have been synthesized by condensation of silylated uracils 2 with methyl 5-O-tert-butyldiphensilyl-2,3-dideoxy-3-iodo-D-threo-pentofuranoside (3) and methyl 5-O-tert-butyldiphenylsilyl-2-deoxy-3-methylsulfonyl-D-erythro-pentofuranoside (8), respectively. The nucleoside 4 and 9 produced the corresponding 2',3'-didehydro-2',3'-dideoxynucleosides 5 in an elimination reaction on treatment with sodium methoxide. The compounds 5b showed no antiviral activity against HIV-1.

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页码：1060 / 1063

页数：4

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