EXPRESSION OF PP60C-SRC IN HUMAN SMALL-CELL AND NON-SMALL-CELL LUNG CARCINOMAS

被引:107
作者
MAZURENKO, NN [1 ]
KOGAN, EA [1 ]
ZBOROVSKAYA, IB [1 ]
KISSELJOV, FL [1 ]
机构
[1] ACAD MED SCI USSR,DEPT PATHOL,MOSCOW 109801,USSR
关键词
D O I
10.1016/S0959-8049(05)80056-5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
c-src protein was found in 60% of lung carcinomas (20 of 33 cases or primary tumours) by immunoblotting with a monoclonal antibody (Mab 327) and immunohistochemistry with serum from rabbits bearing tumours induced by Rous sarcoma virus. src protein expression was assessed in 4 small cell lung carcinomas and in an atypical carcinoid of neuroendocrine origin. However, pp60c-src was also found in non-small cell lung carcinomas: in 60-80% of adenocarcinomas and bronchiolo-alveolar cancers and in 50% of squamous cell carcinomas. In the squamous cell carcinomas, src protein was expressed more frequently in poorly differentiated than in well and moderately differentiated carcinomas. Expression of pp60c-src was not found in epithelial cells of histologically unchanged lung tissues. These results show that pp60c-src may be activated in human lung carcinomas of different histopathological types.
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页码:372 / 377
页数:6
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