CAN SOLUBLE-ANTIGENS INDUCE CD8+ CYTOTOXIC T-CELL RESPONSES - A PARADOX REVISITED

被引：68

作者：

RAYCHAUDHURI, S ^{[1
]}

MORROW, WJW ^{[1
]}

机构：

[1] ST BARTHOLOMEWS HOSP, DEPT IMMUNOL, LONDON EC1A 7BE, ENGLAND

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 07期

关键词：

D O I：

10.1016/0167-5699(93)90233-B

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytotoxic T lymphocyte (CTL) induction usually follows processing of antigens via endogenous pathways before presentation on the cell surface in association with MHC class I molecules. Soluble antigens do not, in general, induce specific CTL responses. Here, Syamal Raychaudhuri and John Morrow suggest that a novel adjuvant formulation can elicit CTL responses to soluble antigens and discuss the implications for vaccine development.

引用

页码：344 / 348

页数：5

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