MAINTENANCE OF CELL-VOLUME IN THE CENTRAL-NERVOUS-SYSTEM

被引：34

作者：

STRANGE, K

机构：

[1] Division of Nephrology, Department of Medicine, Hunnewell 3, Children's Hospital, Harvard Medical School, Boston, 02 115, MA

来源：

PEDIATRIC NEPHROLOGY | 1993年 / 7卷 / 05期

关键词：

BRAIN; CENTRAL NERVOUS SYSTEM; OSMOREGULATION; CELL VOLUME REGULATION; RENAL FAILURE; KIDNEY DISEASE;

D O I：

10.1007/BF00852580

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Maintenance of the ionic and osmotic composition and volume of intra- and extracellular fluids in the brain is crucial for normal functioning of the central nervous system (CNS). Osmoregulation in the CNS is mediated by solute and water transport across the blood-brain barrier, choroid plexus and plasma membrane of glial cells and neurons. Despite its clinical and physiological significance, however, little is known about the underlying cellular and molecular mechanisms by which CNS osmotic and ionic balance is maintained. In this review, I will discuss our current understanding of cell volume regulation in the CNS and how it relates to various disease processes, such as hyponatremia, renal failure and hypernatremia. A detailed understanding of brain osmoregulatory processes represents a fundamental physiological problem and is required for the treatment of numerous disease states, particularly those encountered in the practice of nephrology.

引用

页码：689 / 697

页数：9

共 53 条

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