THE PROBLEM OF CHEMICALLY REACTIVE METABOLITES

[1] ENZYMIC CLEAVAGE OF AROMATIC ETHERS [J]. BIOCHEMICAL JOURNAL, 1956, 63 (04) : 634 - 639

[2] EVIDENCE FOR CLARA CELL AS A SITE OF CYTOCHROME P450-DEPENDENT MIXED-FUNCTION OXIDASE ACTIVITY IN LUNG [J]. NATURE, 1977, 269 (5630) : 713 - 715

[3] BOYD MR, 1978, J PHARMACOL EXP THER, V207, P687

[4] SPLIT GENES [J]. SCIENTIFIC AMERICAN, 1981, 244 (05) : 60 - 71

[5] NON-LINEAR PHARMACOKINETICS AND THEIR IMPACT ON TOXICOLOGY - ILLUSTRATED WITH DIOXANE [J]. DRUG METABOLISM REVIEWS, 1982, 13 (06) : 963 - 981

[6] Gillette J R, 1980, Ciba Found Symp, V76, P191

[7] Gillette J.R., 1982, BIOL REACT INTERMED, P931

[8] PERSPECTIVE ON ROLE OF CHEMICALLY REACTIVE METABOLITES OF FOREIGN COMPOUNDS IN TOXICITY .1. CORRELATION OF CHANGES IN COVALENT BINDING OF REACTIVITY METABOLITES WITH CHANGES IN INCIDENCE AND SEVERITY OF TOXICITY [J]. BIOCHEMICAL PHARMACOLOGY, 1974, 23 (20) : 2785 - 2794

[9] EFFECTS OF INDUCTION OF CYTOCHROME-P-450 ENZYMES ON THE CONCENTRATION OF FOREIGN COMPOUNDS AND THEIR METABOLITES AND ON THE TOXICOLOGICAL EFFECTS OF THESE COMPOUNDS [J]. DRUG METABOLISM REVIEWS, 1979, 10 (01) : 59 - 87

[10] PERSPECTIVE ON ROLE OF CHEMICALLY REACTIVE METABOLITES OF FOREIGN COMPOUNDS IN TOXICITY .2. ALTERATIONS IN KINETICS OF COVALENT BINDING [J]. BIOCHEMICAL PHARMACOLOGY, 1974, 23 (21) : 2927 - 2938

[1] ENZYMIC CLEAVAGE OF AROMATIC ETHERS [J]. BIOCHEMICAL JOURNAL, 1956, 63 (04) : 634 - 639

[2] EVIDENCE FOR CLARA CELL AS A SITE OF CYTOCHROME P450-DEPENDENT MIXED-FUNCTION OXIDASE ACTIVITY IN LUNG [J]. NATURE, 1977, 269 (5630) : 713 - 715

[3] BOYD MR, 1978, J PHARMACOL EXP THER, V207, P687

[4] SPLIT GENES [J]. SCIENTIFIC AMERICAN, 1981, 244 (05) : 60 - 71

[5] NON-LINEAR PHARMACOKINETICS AND THEIR IMPACT ON TOXICOLOGY - ILLUSTRATED WITH DIOXANE [J]. DRUG METABOLISM REVIEWS, 1982, 13 (06) : 963 - 981

[6] Gillette J R, 1980, Ciba Found Symp, V76, P191

[7] Gillette J.R., 1982, BIOL REACT INTERMED, P931

[8] PERSPECTIVE ON ROLE OF CHEMICALLY REACTIVE METABOLITES OF FOREIGN COMPOUNDS IN TOXICITY .1. CORRELATION OF CHANGES IN COVALENT BINDING OF REACTIVITY METABOLITES WITH CHANGES IN INCIDENCE AND SEVERITY OF TOXICITY [J]. BIOCHEMICAL PHARMACOLOGY, 1974, 23 (20) : 2785 - 2794

[9] EFFECTS OF INDUCTION OF CYTOCHROME-P-450 ENZYMES ON THE CONCENTRATION OF FOREIGN COMPOUNDS AND THEIR METABOLITES AND ON THE TOXICOLOGICAL EFFECTS OF THESE COMPOUNDS [J]. DRUG METABOLISM REVIEWS, 1979, 10 (01) : 59 - 87

[10] PERSPECTIVE ON ROLE OF CHEMICALLY REACTIVE METABOLITES OF FOREIGN COMPOUNDS IN TOXICITY .2. ALTERATIONS IN KINETICS OF COVALENT BINDING [J]. BIOCHEMICAL PHARMACOLOGY, 1974, 23 (21) : 2927 - 2938