PREDICTORS OF DISABILITY IN A LONGITUDINAL SAMPLE OF PATIENTS WITH RHEUMATOID-ARTHRITIS

被引:86
作者
LEIGH, JP [1 ]
FRIES, JF [1 ]
机构
[1] STANFORD UNIV,MED CTR,SCH MED,DEPT MED,STANFORD,CA 94305
关键词
D O I
10.1136/ard.51.5.581
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Information from the Health Assessment Questionnaire (HAQ) is used to identify which variables measured in 1981 successfully predict the severity of disease in 1989 and the eight year change in severity of disease in a sample of 330 residents of Santa Clara County, California, USA. This study is exploratory and no previous hypotheses are made. Using univariate correlations and stepwise linear regressions, initial values of a number of variables are found to be useful predictors including, in order: the HAQ disability index, pain scale, global health status, tender joints, few workhours, age, female sex, never married, widowhood, and occupation as operative (e.g. dry wall installers, assemblers). Data suggest that deterioration over eight years is least rapid for those with severe disease in 1981. A mathematical identity suggests that analyses of the changes in severity versus analyses of 1989 severity are identical, provided that the 1981 disability index is entered as a covariate. The initial level of the disability index of the HAQ is by far the strongest predictive variable and provides a clinically important gauge for the likelihood of future impairment.
引用
收藏
页码:581 / 587
页数:7
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