URINARY N-ACETYL-BETA-D-GLUCOSAMINIDASE ACTIVITY IN LEAD-EXPOSED WORKERS

被引：30

作者：

ENDO, G

HORIGUCHI, S

KIYOTA, I

机构：

[1] Department of Preventive Medicine and Environmental Health, Osaka City University Medical School, Osaka, 545, 1-4-54 Asahimachi, Abeno-ku

来源：

JOURNAL OF APPLIED TOXICOLOGY | 1990年 / 10卷 / 04期

关键词：

blood lead; lead; NAG; nephrotoxicity; N‐acetyl‐β‐D‐glucosaminidase; occupational exposure; renal function;

D O I：

10.1002/jat.2550100402

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The adverse effects of long‐term exposure to lead dust on renal tubular functions were studied in 39 male and 7 female workers in a secondary lead refinery. Laboratory examinations showed low or moderate lead absorption levels. The N‐acetyl‐β‐D‐glucosaminidase (NAG) activity in urine showed significant correlation with each of the lead exposure indices. NAG activity increased remarkably in lead workers with blood lead (PbB) above 80 μg 100g−1. Blood urea nitrogen (BUN) showed significant correlation with PbB and logarithmic urine δ‐amino‐levulinic acid (log(ALAU)), but not with urine lead (PbU) and logarithmic urine coproporphyrin (log(CPU)). All the other indices of renal function were almost within the normal range and showed no correlation with lead indices. This study suggests that moderate lead absorption may cause renal tubular impairment, and NAG can be one of the most sensitive indices for estimating renal dysfunction due to lead poisoning. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：235 / 238

页数：4

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