EFFECT OF THE LEUKOTRIENE B4 RECEPTOR ANTAGONIST, SC-41930, ON EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS (EAE) IN THE GUINEA-PIG

被引：14

作者：

FRETLAND, DJ ^{[1
]}

WIDOMSKI, DL ^{[1
]}

SHONE, RL ^{[1
]}

LEVIN, S ^{[1
]}

GAGINELLA, TS ^{[1
]}

机构：

[1] SEARLE RES & DEV,DEPT PATHOL,SKOKIE,IL 60077

来源：

AGENTS AND ACTIONS | 1991年 / 34卷 / 1-2期

关键词：

D O I：

10.1007/BF01993269

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The accepted model for the human demyelinating disease, multiple sclerosis (MS), is experimental allergic encephalomyelitis (EAE). We assessed the ability of SC-41930(7-[3(4-acetyl-3-methoxy-2-propylphenoxy)-propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxyl acid), to modulate the symptoms of acute EAE generated in guinea pigs. Animals were pretreated with SC-41930 (20 mg/kg, i.p.) for two days followed by thrice-weekly maintenance. At day 52, a significant number of the SC-41930-treated animals were alive as compared to EAE alone. Control animals had an increase in body weight while EAE animals lost over 20% (p < 0.5) of their body weight by day 18. SC-41930-treatment significantly reduced, but did not completely inhibit the cachectic response. The results indirectly implicate LTB4 in the pathogenesis of EAE. Agents that modify this model be useful in the treatment of human MS.

引用

页码：172 / 174

页数：3

共 8 条

[1] PHARMACOLOGICAL COMPARISON OF ACTIVE AND PASSIVE EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN THE RAT [J].