CELL-KINETICS - AN INDEPENDENT PROGNOSTIC VARIABLE IN STAGE-II MELANOMA OF THE SKIN

被引：9

作者：

COSTA, A ^{[1
]}

SILVESTRINI, R ^{[1
]}

MEZZANOTTE, G ^{[1
]}

VAGLINI, M ^{[1
]}

GRIGNOLIO, E ^{[1
]}

CLEMENTE, C ^{[1
]}

CASCINELLI, N ^{[1
]}

机构：

[1] IST NAZL TUMORI, VIA VENEZIAN 1, I-20133 MILAN, ITALY

来源：

BRITISH JOURNAL OF CANCER | 1990年 / 62卷 / 05期

关键词：

D O I：

10.1038/bjc.1990.386

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prognostic role of cell kinetics (expressed as 3H-thymidine labelling index,3H-TdR LI) was assessed on 145 patients with pathologic stage II melanoma subjected only to therapeutic lymph node dissection. The 3H-TdR LI determined on metastatic nodes was related to relapse-free survival and to survival. In particular, 3-year relapse-free survival was significantly different from patients with slowly and rapidly proliferating melanomas (40% vs 22%, P=0. 007), and this finding was consistently found for overall survival (68% vs 46%, P=0. 007). Moreover, in patients with high 3H-TdR LI tumours, the risk of relapse and death within the first year from lymphadenectomy was two-fold that of patients with low 3H-TdR LI tumours. Multiple regression analysis showed that 3H-TdR LI retained its prognostic significance on relapse-free and on overall survival even when the number of involved nodes and type of nodal metastases were considered. Present findings suggest that 3H-TdR LI can contribute to select high-risk stage II melanoma patients. © Macmillan Press Ltd., 1990.

引用

页码：826 / 829

页数：4

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