DIFFERENTIAL INHIBITION OF FAT INTAKE IN 2 STRAINS OF RAT BY THE PEPTIDE ENTEROSTATIN

被引：102

作者：

OKADA, S

YORK, DA

BRAY, GA

MEI, J

ERLANSONALBERTSSON, C

机构：

[1] PENNINGTON BIOMED RES CTR, 6400 PERKINS RD, BATON ROUGE, LA 70808 USA

[2] UNIV LUND, DEPT MED & PHYSIOL CHEM, S-22101 LUND, SWEDEN

来源：

AMERICAN JOURNAL OF PHYSIOLOGY | 1992年 / 262卷 / 06期

关键词：

FOOD INTAKE; OSBORNE-MENDEL RATS; S5B P1 RATS; MACRONUTRIENTS; NUTRIENT-SPECIFIC SATIETY;

D O I：

10.1152/ajpregu.1992.262.6.R1111

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The effect of enterostatin, the amino-terminal pentapeptide of pancreatic procolipase, on food intake was investigated in two strains of rat, the dietary fat-sensitive Osborne-Mendel (OM) rat and the dietary fat-resistant S5B/Pl rat. After an overnight fast, enterostatin inhibited intake of high-fat (HF) but not low-fat (LF) diets in OM rats, but had no effect in S5B/Pl rats. When fed a macronutrient three-choice diet, OM rats selected fat preferentially, whereas S5B/Pl rats selected carbohydrate. Enterostatin specifically inhibited the intake of fat in OM rats but not S5B/Pl rats fed a three-choice macronutrient diet. The activity of pancreatic colipase was increased in S5B/Pl rats on both HF and LF diets compared with OM rats. Pancreatic colipase activities were negatively related to the voluntary intake of fat on three-choice macronutrient diets. The data support the hypothesis that enterostatin may control the intake of dietary fat.

引用

页码：R1111 / R1116

页数：6

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