DIVERGENCE OF BIOLOGICAL AND CHRONOLOGICAL AGING - EVIDENCE FROM RODENT STUDIES

被引：73

作者：

COLLIER, TJ

COLEMAN, PD

机构：

[1] Department of Neurobiology and Anatomy, University of Rochester School of Medicine, Rochester, NY 14642

来源：

NEUROBIOLOGY OF AGING | 1991年 / 12卷 / 06期

关键词：

AGING; RODENTS; MOTOR BEHAVIOR; COGNITIVE BEHAVIOR; LEARNING; MEMORY; NEOPHOBIA; GENETICS; HANDLING; FOOD RESTRICTION; CENTROPHENOXINE; ACETYL-L-CARNITINE;

D O I：

10.1016/0197-4580(91)90122-Z

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Literature on aging populations of rodents supports the intuitive view that significant functional variation exists among like-aged, elderly individuals: chronological age as a solitary measure is a poor indicator of biological age. In this report, we review a variety of studies which classify aged rodents based on genetic and/or behavioral similarities, in addition to chronological age, and have provided valuable neurobiological and physiological information on age-related changes which accompany functional impairments, or the lack of them. Beyond their descriptive value for gerontological research, these findings suggest ways in which biological aging can be manipulated to promote good function in aged individuals.

引用

页码：685 / 693

页数：9

共 66 条

[1]

ABBEY H, 1978, US DHEW NIH79161 PUB, P1

[2] ACETYL-1-CARNITINE .2. EFFECTS ON LEARNING AND MEMORY PERFORMANCE OF AGED RATS IN SIMPLE AND COMPLEX MAZES [J].