IMMUNOCYTOCHEMICAL COLOCALIZATION OF SUBSTANCE-P AND CALCITONIN-GENE-RELATED PEPTIDE IN AFFERENT RENAL NERVE SOMA OF THE RAT

被引：16

作者：

BURG, M

ZAHM, DS

KNUEPFER, MM

机构：

[1] ST LOUIS UNIV,SCH MED,DEPT PHARMACOL & PHYSIOL SCI,ST LOUIS,MO 63104

[2] ST LOUIS UNIV,SCH MED,DEPT ANAT & NEUROBIOL,ST LOUIS,MO 63104

来源：

NEUROSCIENCE LETTERS | 1994年 / 173卷 / 1-2期

关键词：

AFFERENT RENAL NERVE; SUBSTANCE P; CALCITONIN GENE-RELATED PEPTIDE; DORSAL ROOT GANGLIA; COLOCALIZATION; RETROGRADE TRACING; FLUORESCENT DYE;

D O I：

10.1016/0304-3940(94)90156-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Substance P, calcitonin gene-related peptide and somatostatin immunoreactivities have been demonstrated in putative afferent renal nerve fibers in the rat. Utilizing retrograde-tracing and immunohistochemistry, we labeled afferent renal nerve soma throughout dorsal root ganglia T9 to L1. Most (85%) of afferent renal nerve perikarya were immunoreactive for calcitonin gene-related peptide, 21% had substance P immunoreactivity and none had somatostatin immunoreactivity. Air renal afferents immunoreactive for substance P also contained calcitonin gene-related peptide. These results provide evidence that calcitonin gene-related peptide and substance P are present and co-localized in afferent renal nerves, and therefore, mediate transmission of afferent renal input to the spinal cord in the rat.

引用

页码：87 / 93

页数：7

共 22 条

[1] LOCALIZATION OF RENAL SENSORY NEURONS USING THE FLUORESCENT DYE TECHNIQUE [J].

DONOVAN, MK ;

WYSS, JM ;

WINTERNITZ, SR .

BRAIN RESEARCH, 1983, 259 (01) :119-122

[2] ULTRASTRUCTURAL-LOCALIZATION AND CHARACTERIZATION OF SENSORY NERVES IN THE RAT-KIDNEY [J].

FERGUSON, M ;

BELL, C .

JOURNAL OF COMPARATIVE NEUROLOGY, 1988, 274 (01) :9-16

[3]

GODEMENT P, 1987, DEVELOPMENT, V101, P697

[4]

GREEN T, 1988, NEUROSCIENCE, V25, P181

[5] STUDIES ON THE COEXISTENCE OF SUBSTANCE-P WITH OTHER PUTATIVE TRANSMITTERS IN THE NODOSE AND PETROSAL GANGLIA [J].

HELKE, CJ ;

NIEDERER, AJ .

SYNAPSE, 1990, 5 (02) :144-151

[6]

JU G, 1987, CELL TISSUE RES, V247, P417

[7] INCREASE IN SUBSTANCE-P IN THE DORSAL HORN DURING A CHEMOGENIC NOCICEPTIVE STIMULUS [J].

KANTNER, RM ;

KIRBY, ML ;

GOLDSTEIN, BD .

BRAIN RESEARCH, 1985, 338 (01) :196-199

[8] IDENTIFICATION OF NEUROPEPTIDES IN PELVIC AND PUDENDAL NERVE AFFERENT PATHWAYS TO THE SACRAL SPINAL-CORD OF THE CAT [J].

KAWATANI, M ;

NAGEL, J ;

DEGROAT, WC .

JOURNAL OF COMPARATIVE NEUROLOGY, 1986, 249 (01) :117-132

[9] CALCITONIN GENE-RELATED PEPTIDE-IMMUNOREACTIVE NERVES IN THE RAT-KIDNEY [J].

KNIGHT, DS ;

CICERO, S ;

BEAL, JA .

AMERICAN JOURNAL OF ANATOMY, 1991, 190 (01) :31-40

[10]

KNUEPFER MM, 1987, BRAIN RES, V435, P167

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