GLUCOCORTICOID-INDUCED G1 ARREST AND THE RELEASE EFFECT OF EPIDERMAL GROWTH-FACTOR ON THE HUMAN SALIVARY-GLAND ADENOCARCINOMA CELL

被引：11

作者：

HATAKEYAMA, S ^{[1
]}

SUZUKI, A ^{[1
]}

YOSHIZUMI, N ^{[1
]}

SATO, M ^{[1
]}

NISHIYA, I ^{[1
]}

机构：

[1] IWATE MED UNIV,SCH MED,DEPT OBSTET & GYNAECOL,MORIOKA,IWATE 020,JAPAN

来源：

CELL BIOLOGY INTERNATIONAL REPORTS | 1991年 / 15卷 / 01期

关键词：

D O I：

10.1016/0309-1651(91)90082-T

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dexamethasone (1 μM) decreased the distribution of cells in S phase (about 75%) and increased that of G1 cells (1.1-fold) in the DNA histogram of human submandibular salivary gland adenocarcinoma cells (HSG) reversibly. In synchronized cells at G1 phase, glucocorticoid delayed the initiation of DNA synthesis by about 3-4 h. The conditioned medium (50%) or exogenous human epidermal growth factor (EGF, 10 ng/ml) significantly nullified these effects by glucocorticoids. These results suggested that glucocorticoids arrested the cells at G1 phase, which implied the inhibition of production of some progressive factor, probably EGF, in the cell cycle of HSG. © 1991.

引用

页码：55 / 65

页数：11

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