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THE STRUCTURE OF THYROID AUTOANTIGENS

被引：24
作者：
FURMANIAK, J
SMITH, BR
机构：
[1] Endocrine Immunology Unit, University of Wales College of Medicine, Cardiff, CF4 4XN, 7th floor, Heath Park
来源：
AUTOIMMUNITY | 1990年 / 7卷 / 01期
关键词：
D O I：
10.3109/08916939009041051
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
There are three distinct and well characterized thyroid autoantigens-thyroglobulin (Tg), thyroid peroxidase (microsomal antigen/TPO) and the TSH receptor. Auto-antibodies to the TSH receptor are responsible for hyperthyroidism in Graves' disease whereas antibodies to TPO and Tg are associated with the hypothyroidism of Hashimoto's disease and primary myxoedema. However TPO antibodies (and to a lesser extent Tg antibodies) are also found in Graves' disease. This review summarises the current state of knowledge regarding the structure of the 3 thyroid autoantigens with particular emphasis on their interaction with auto-antibodies. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：63 / 80
页数：18
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