THE 5-HT1A AGONIST 8-OH-DPAT ATTENUATES THE SATIATING ACTION OF CHOLECYSTOKININ

被引：35

作者：

POESCHLA, B

GIBBS, J

SIMANSKY, KJ

SMITH, GP

机构：

[1] CORNELL UNIV,COLL MED,DEPT PSYCHIAT,WHITE PLAINS,NY 10605

[2] EASTERN PENN PSYCHIAT INST,MED COLL PENN,DEPT PHARMACOL,PHILADELPHIA,PA 19129

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 42卷 / 03期

关键词：

BRAIN-GUT PEPTIDES; BRAIN-GUT INTERACTIONS; CHOLECYSTOKININ; CONTROL OF FOOD INTAKE; 5-HT1A RECEPTORS; 8-OH-DPAT; SATIETY; SEROTONIN;

D O I：

10.1016/0091-3057(92)90152-6

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

To investigate the dependence of the satiating action of cholecystokinin (CCK) on serotonergic action at central 5-HT receptors, we examined the effect of systemic pretreatment with 8-OH-DPAT (a 5-HT1A agonist that decreases central 5-HT synthesis and release via an action at somatodendritic autoreceptors in the brainstem raphe) on the suppression of food intake induced by systemic administration of cholecystokinin octapeptide (CKK-8). 8-OH-DPAT significantly attenuated the satiating action of CKK-8. This result is consistent with the hypothesis that peripherally acting CCK recruits central serotonergic processes to elicit normal satiety.

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收藏

页码：541 / 543

页数：3

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