CHARACTERIZATION OF THE RESPONSE OF GROWTH AND DIFFERENTIATION TO LIPOPROTEINS AND AGENTS AFFECTING CHOLESTEROL-METABOLISM IN MURINE NEUROBLASTOMA-CELLS

被引：5

作者：

CASTELLANO, F ^{[1
]}

BRUSCALUPI, G ^{[1
]}

COLUMBA, S ^{[1
]}

DICROCE, L ^{[1
]}

TRENTALANCE, A ^{[1
]}

AUGUSTITOCCO, G ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,DIPARTIMENTO BIOL CELLULARE & SVILUPPO,I-00185 ROME,ITALY

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 1994年 / 12卷 / 01期

关键词：

NEUROBLASTOMA CELLS; HMGCOA REDUCTASE; HIGH DENSITY LIPOPROTEINS; MEVINOLIN;

D O I：

10.1016/0736-5748(94)90098-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Treatment with mevinolin, a competitive inhibitor of HMGCoAR, the key enzyme of isoprenoid metabolism, causes the arrest of proliferation and the differentiation of a neuroblastoma cell line (N18TG2). Mevalonate and high density lipoproteins partially restore growth. Cholesterol synthesis in the presence of mevinolin remains active, because in these cells the key enzyme HMG-CoA reductase is not completely inhibited by this drug. The fact that cell growth is reduced, while cholesterogenesis remains active, suggests that mevinolin acts by interfering with the synthesis of some unknown compound, other than cholesterol, which is necessary for proliferation.

引用

页码：77 / 84

页数：8

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