HEREDITARY PAPILLARY RENAL-CELL CARCINOMA

被引：181

作者：

ZBAR, B

TORY, K

MERINO, M

SCHMIDT, L

GLENN, G

CHOYKE, P

WALTHER, MM

LERMAN, M

LINEHAN, WM

机构：

[1] DYNACORP INC,PROGRAM RESOURCES INC,FREDERICK,MD

[2] NIH,CANC DIAG BRANCH,PATHOL LAB,SURG BRANCH,IMMUNOBIOL LAB,BETHESDA,MD

[3] NIH,DEPT DIAGNOST RADIOL,BETHESDA,MD

来源：

JOURNAL OF UROLOGY | 1994年 / 151卷 / 03期

关键词：

CARCINOMA; RENAL CELL; KIDNEY NEOPLASMS; HEREDITARY DISEASES;

D O I：

10.1016/S0022-5347(17)35015-2

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We describe a 3 generation family with members affected with papillary renal cell carcinoma, an uncommon histological type of renal cell carcinoma. Multiple tumors of varying size were present in both kidneys of affected family members. The disorder was not linked to polymorphic markers on chromosome 3p and there was no loss of heterozygosity at loci on 3p in renal tumors. The results suggest the presence of a renal cell carcinoma gene not located on 3p that predisposes to renal cell carcinoma with a distinct histological appearance. The inherited disorder in this family appears to be different from recognized hereditary cancer syndromes.

引用

页码：561 / 566

页数：6

共 30 条

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