EFFECT OF INDOMETHACIN-COATED POSTERIOR CHAMBER INTRAOCULAR LENSES ON POSTOPERATIVE INFLAMMATION AND POSTERIOR CAPSULE OPACIFICATION

被引：48

作者：

NISHI, O

NISHI, K

YAMADA, Y

MIZUMOTO, Y

机构：

[1] The Nishi Eye Hospital, Osaka

[2] Menicon Co., Ltd., Nagoya

来源：

JOURNAL OF CATARACT AND REFRACTIVE SURGERY | 1995年 / 21卷 / 05期

关键词：

BIOCOMPATIBILITY; BLOOD-AQUEOUS BARRIER; INDOMETHACIN; INFLAMMATION; INTRAOCULAR LENS; NONSTEROIDAL ANTIINFLAMMATORY DRUG; POSTERIOR CAPSULE OPACIFICATION; SURFACE MODIFICATION;

D O I：

10.1016/S0886-3350(13)80220-9

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

We implanted indomethacin-coated intraocular lenses (IOLs) in rabbit eyes to ascertain how the sustained release of the drug affects postoperative inflammation and posterior capsule opacification (PCO). A preoperative resolution test showed that 1% indomethacin-coated IOLs placed in balanced salt solution released a mean 14.0 +/- 0.6 mu g of the drug within 24 hours. Postoperatively, aqueous flare intensity in eyes with 0.1% indomethacin-coated IOLs and in eyes with 1.0% indomethacin-coated IOLs was significantly less at day 2 and at days 2 and 3, respectively, than in control eyes with uncoated lenses. In another group of eyes, histopathological examination showed that those with 1.0% indomethacin-coated lenses had significantly less PCO than the contralateral control eyes with uncoated IOLs.

引用

页码：574 / 578

页数：5

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