THE DEATH DOMAIN MOTIF FOUND IN FAS (APO-1) AND TNF RECEPTOR IS PRESENT IN PROTEINS INVOLVED IN APOPTOSIS AND AXONAL GUIDANCE

被引：103

作者：

HOFMANN, K

TSCHOPP, J

机构：

[1] UNIV LAUSANNE,INST BIOCHEM,CH-1066 EPALINGES,SWITZERLAND

[2] UNIV LAUSANNE,SWISS INST CANC RES,CH-1066 EPALINGES,SWITZERLAND

来源：

FEBS LETTERS | 1995年 / 371卷 / 03期

关键词：

FAS; APO-1; TNF RECEPTOR; DEATH DOMAIN; APOPTOSIS; NEURON GUIDANCE; REAPER; RETINOBLASTOMA; UNC; ANKYRIN;

D O I：

10.1016/0014-5793(95)00931-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction of Fas (Apo-1) and TNF receptor-1 with their respective ligands can lead to cell death. The so-called death domain, a sequence motif present in the cytoplasmic portion of the two receptors, has been identified as a critical structural element involved in signal transduction that leads to apoptosis. Here we describe several additional proteins which contain a death domain, Novel members of this family include proteins known to be implicated not only in apoptosis but also in neuron guidance.

引用

页码：321 / 323

页数：3

共 27 条

[1] BASIC LOCAL ALIGNMENT SEARCH TOOL
ALTSCHUL, SF
GISH, W
MILLER, W
MYERS, EW
LIPMAN, DJ
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) : 403 - 410
[2] GENBANK
BENSON, DA
BOGUSKI, M
LIPMAN, DJ
OSTELL, J
[J]. NUCLEIC ACIDS RESEARCH, 1994, 22 (17) : 3441 - 3444
[3] A NOVEL PROTEIN THAT INTERACTS WITH THE DEATH DOMAIN OF FAS/APO1 CONTAINS A SEQUENCE MOTIF RELATED TO THE DEATH DOMAIN
BOLDIN, MP
VARFOLOMEEV, EE
PANCER, Z
METT, IL
CAMONIS, JH
WALLACH, D
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (14) : 7795 - 7798
[4] SELF-ASSOCIATION OF THE DEATH DOMAINS OF THE P55 TUMOR-NECROSIS-FACTOR (TNF) RECEPTOR AND FAS/APO1 PROMPTS SIGNALING FOR TNF AND FAS/APO1 EFFECTS
BOLDIN, MP
METT, IL
VARFOLOMEEV, EE
CHUMAKOV, I
SHEMERAVNI, Y
CAMONIS, JH
WALLACH, D
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (01) : 387 - 391
[5] BUCHER P, 1994, 2ND P INT C INT SYST, P53
[6] FADD, A NOVEL DEATH DOMAIN-CONTAINING PROTEIN, INTERACTS WITH THE DEATH DOMAIN OF FAS AND INITIATES APOPTOSIS
CHINNAIYAN, AM
OROURKE, K
TEWARI, M
DIXIT, VM
[J]. CELL, 1995, 81 (04) : 505 - 512
[7] REQUIREMENT FOR A FUNCTIONAL RB-1 GENE IN MURINE DEVELOPMENT
CLARKE, AR
MAANDAG, ER
VANROON, M
VANDERLUGT, NMT
VANDERVALK, M
HOOPER, ML
BERNS, A
RIELE, HT
[J]. NATURE, 1992, 359 (6393) : 328 - 330
[8] IDENTIFICATION OF A NOVEL SERINE THREONINE KINASE AND A NOVEL 15-KD PROTEIN AS POTENTIAL MEDIATORS OF THE GAMMA-INTERFERON-INDUCED CELL-DEATH
DEISS, LP
FEINSTEIN, E
BERISSI, H
COHEN, O
KIMCHI, A
[J]. GENES & DEVELOPMENT, 1995, 9 (01) : 15 - 30
[9] THE AMINO-TERMINAL REGION OF THE RETINOBLASTOMA GENE-PRODUCT BINDS A NOVEL NUCLEAR MATRIX PROTEIN THAT COLOCALIZES TO CENTERS FOR RNA PROCESSING
DURFEE, T
MANCINI, MA
JONES, D
ELLEDGE, SJ
LEE, WH
[J]. JOURNAL OF CELL BIOLOGY, 1994, 127 (03) : 609 - 622
[10] HOMOLOGY BETWEEN REAPER AND THE CELL-DEATH DOMAINS OF FAS AND TNFR1
GOLSTEIN, P
MARGUET, D
DEPRAETERE, V
[J]. CELL, 1995, 81 (02) : 185 - 186

← 1 2 3 →