ACETYLCHOLINE-RELEASE DETECTED BY TRANSSTRIATAL DIALYSIS IN FREELY MOVING RATS CORRELATES WITH SPONTANEOUS MOTOR-ACTIVITY

被引：21

作者：

WATANABE, H

SHIMIZU, H

MATSUMOTO, K

机构：

[1] Section of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, Toyama

来源：

LIFE SCIENCES | 1990年 / 47卷 / 09期

关键词：

D O I：

10.1016/0024-3205(90)90556-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In vivo acetylcholine (ACh) release from the anterior, middle, or posterior striatum and the level of spontaneous motor activity were determined simultaneously using transtriatal dialysis in freely moving rats. Spontaneous ACh release from the middle striatum was higher than from either the anterior or posterior striatum and correlated with the level of spontaneous motor activity. These findings indicate that drug-induced striatal ACh release could be modified by changes of the level of motor activity in freely moving rats. © 1990.

引用

页码：829 / 832

页数：4

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