NALOXONE ENHANCES EPILEPTOGENIC AND BEHAVIORAL-EFFECTS OF PENTAZOCINE IN RATS

被引：7

作者：

DIRKSEN, R ^{[1
]}

COENEN, AML ^{[1
]}

VANLUIJTELAAR, ELJM ^{[1
]}

机构：

[1] CATHOLIC UNIV NIJMEGEN,DEPT PSYCHOL,6500 HB NIJMEGEN,NETHERLANDS

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 39卷 / 02期

关键词：

PENTAZOCINE; EPILEPSY; NALOXONE; RATS; EEG; BEHAVIOR;

D O I：

10.1016/0091-3057(91)90200-L

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Eight groups of six rats were either injected with saline, pentazocine, naloxone, or a combination of pentazocine and naloxone. Studied were the effects on EEG and behavior. It was found that pentazocine induced epileptic seizures in a dose-dependent fashion. In addition, similar behavioral changes were present after all three doses of pentazocine. High doses of naloxone did not cause epilepsy and affected behavior only slightly. Seizures induced by pentazocine were not antagonized by the opiate antagonist naloxone, but were facilitated after the combination of a noneffective dose of pentazocine and a noneffective dose of naloxone. In addition, exploratory behavior was facilitated by the combination of pentazocine and naloxone. It seems that both an opiate and a nonopiate system are involved in this type of epilepsy and in this type of behavior.

引用

页码：415 / 420

页数：6

共 27 条

[1]

ALARCON RD, 1971, JOHNS HOPKINS MED J, V129, P311

[2]

[Anonymous], 1971, STAT PRINCIPLES EXPT

[3] TONIC-CLONIC ACTIVITY AFTER SUFENTANIL [J].

BRIAN, JE ;

SEIFEN, AB .

ANESTHESIA AND ANALGESIA, 1987, 66 (05) :481-481

[4] EFFECTS OF DIAZEPAM AND 2 BETA-CARBOLINES ON EPILEPTIC ACTIVITY AND ON EEG AND BEHAVIOR IN RATS WITH ABSENCE SEIZURES [J].

COENEN, AML ;

VANLUIJTELAAR, ELJM .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1989, 32 (01) :27-35

[5]

COENEN AML, 1974, PHYSIOL BEHAV, V14, P391

[6] AGONISTIC PROPERTIES OF NARCOTIC ANALGESICS AND ANTAGONISTS ON ELECTROENCEPHALOGRAM AND BEHAVIOR IN RAT AND THEIR REVERSAL BY NALOXONE [J].

COLASANTI, B ;

KHAZAN, N .

NEUROPHARMACOLOGY, 1973, 12 (07) :619-627

[7] CLASSIFICATION OF OPIOIDS ON THE BASIS OF CHANGE IN SEIZURE THRESHOLD IN RATS [J].

COWAN, A ;

GELLER, EB ;

ADLER, MW .

SCIENCE, 1979, 206 (4417) :465-467

[8] EFFECT OF MORPHINE AND MORPHINE-LIKE ANALGESICS ON SUSCEPTIBILITY TO SEIZURES IN MICE [J].

CZUCZWAR, SJ ;

FREY, HH .

NEUROPHARMACOLOGY, 1986, 25 (05) :465-469

[9] NALOXONE AS A GABA ANTAGONIST - EVIDENCE FROM IONTOPHORETIC, RECEPTOR-BINDING AND CONVULSANT STUDIES [J].

DINGLEDINE, R ;

IVERSEN, LL ;

BREUKER, E .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 47 (01) :19-27

[10]

DIRKSEN R, 1990, EUR J ANAESTHESIOL S, V53, P3

← 1 2 3 →