ACTIVATION OF LYMPHOCYTES BY VARICELLA-ZOSTER VIRUS (VZV) - EXPRESSION OF INTERLEUKIN-2 RECEPTORS ON LYMPHOCYTES CULTURED WITH VZV ANTIGEN

被引：20

作者：

ITO, M ^{[1
]}

NAKANO, T ^{[1
]}

KAMIYA, T ^{[1
]}

KITAMURA, K ^{[1
]}

KOMADA, Y ^{[1
]}

IHARA, T ^{[1
]}

KAMIYA, H ^{[1
]}

SAKURAI, M ^{[1
]}

机构：

[1] MIE NATL HOSP,DEPT PEDIAT,TSU,JAPAN

来源：

JOURNAL OF INFECTIOUS DISEASES | 1992年 / 165卷 / 01期

关键词：

D O I：

10.1093/infdis/165.1.158

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The expression of human leukocyte antigen (HLA-DR) and interleukin-2 receptor (IL-2R; alpha and beta-subunits) was significantly increased in peripheral blood mononuclear cells (PBMC) from varicella-zoster virus (VZV)-seropositive donors when PBMC were cultured with VZV antigen for 6 days. The increased expression of HLA-DR and IL-2R was observed in both CD4+ and CD8+ lymphocytes, which suggests that both types of lymphocytes from VZV-seropositive donors were activated when PBMC were cultured with VZV antigen. Adding anti-IL-2R-alpha did not inhibit lymphocyte proliferation in response to VZV antigen, although marked inhibition was obtained by adding anti-IL-2R-beta. No IL-2 was detected in the supernatant of PBMC cultured with VZV antigen; however, antibody to IL-2 inhibited lymphocyte proliferation on exposure to VZV antigen. These results indicate that IL-2 and expression of IL-2R-beta are essential to lymphocyte activation by VZV antigen.

引用

页码：158 / 161

页数：4

共 14 条

[1]

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[2]

FELDMAN S, 1975, PEDIATRICS, V56, P388

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