FAD-LINKED GLYCEROPHOSPHATE DEHYDROGENASE-DEFICIENCY IN PANCREATIC-ISLETS OF MICE WITH HEREDITARY DIABETES

被引：35

作者：

SENER, A

HERBERG, L

MALAISSE, WJ

机构：

[1] FREE UNIV BRUSSELS,ERASMUS MED SCH,EXPTL MED LAB,808 ROUTE LENNIK,B-1070 BRUSSELS,BELGIUM

[2] UNIV DUSSELDORF,DIABET FORSCHUNGSINST,W-4000 DUSSELDORF 1,GERMANY

来源：

FEBS LETTERS | 1993年 / 316卷 / 03期

关键词：

PANCREATIC ISLET; FAD-LINKED GLYCEROPHOSPHATE DEHYDROGENASE; DB/DB MOUSE;

D O I：

10.1016/0014-5793(93)81297-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mitochondrial enzyme FAD-linked glycerophosphate dehydrogenase plays a key role in the glucose-sensing device of the insulin-producing pancreatic B-cell. Its activity was found to be decreased in islet, but not liver, homogenates of BL/Ks-db/db mice, in which diabetes mellitus represents an inherited disease. The decreased activity of FAD-linked glycerophosphate dehydrogenase contrasted with a normal activity of glutamate dehydrogenase and 2-ketoglutarate dehydrogenase in the islets of db/db mice. It is proposed that a site-specific defect of FAD-linked glycerophosphate dehydrogenase in the pancreatic B-cell might represent a far-from-uncommon causal or contributing factor in the pathogenesis of non-insulin-dependent diabetes mellitus.

引用

页码：224 / 227

页数：4

共 28 条

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