The effects of social support, job control, participative decision making practices, and locus of control upon the relationship between occupational stress and psychological well-being have been well discussed and researched. In order to synthesize these areas of research, a 1-month follow-up study of 244 accountants was conducted. The results indicated complex interactions between stressors, locus of control, and social support or job autonomy in predicting psychological well-being, controlling for initial measures of well-being. These interactions reveal that an internal locus of control, and social support/job autonomy synergistically buffer the effects of stressors upon well-being.