INHIBITORY EFFECT OF A NEW ANTIBIOTIC, GUANINE 7-N-OXIDE, ON THE REPLICATION OF SEVERAL RNA VIRUSES

被引：3

作者：

YAMAMOTO, K

KITANO, T

ARAI, YT

YOSHII, K

HASOBE, M

SANEYOSHI, M

机构：

[1] NATL INST HLTH, DEPT ENTEROVIRUSES, TOKYO 141, JAPAN

[2] TOKYO UNIV FISHERIES, FISH PATHOL LAB, TOKYO 108, JAPAN

[3] HOKKAIDO UNIV, DEPT PHARMACEUT SCI, SAPPORO, HOKKAIDO 060, JAPAN

来源：

ANTIVIRAL RESEARCH | 1990年 / 14卷 / 03期

关键词：

Anti-RNA virus activity; Guanine; 7-N-oxide;

D O I：

10.1016/0166-3542(90)90033-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Guanine 7-N-oxide (G-7-Ox) was examined for its antiviral activity against 9 viruses based on plaque reduction, neuraminidase activity reduction, a fluorescent antibody technique or ELISA. The following viruses were included in the tests: influenza, Sendai, simian virus 5 (SV5), respiratory syncytial, western equine encephalitis, Japanese encephalitis, vesicular stomatitis, rabies and polio. G-7-Ox showed broad anti-RNA viral activity against all viruses tested, except for poliovirus. Inhibition of persistent SV5 infection by G-7-Ox indicates that its antiviral activity is independent of cytotoxicity. © 1990.

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页码：173 / 178

页数：6

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