DIFFUSION IN POROUS MATERIALS ABOVE THE PERCOLATION-THRESHOLD

被引：28

作者：

HASTEDT, JE

WRIGHT, JL

机构：

[1] BOEHRINGER INGELHEIM PHARMACEUT INC, 175 BRIAR RIDGE RD, RIDGEFIELD, CT 06877 USA

[2] UNIV WISCONSIN, SCH PHARM, MADISON, WI 53706 USA

来源：

PHARMACEUTICAL RESEARCH | 1990年 / 7卷 / 09期

关键词：

conductivity; diffusion; matrix release; percolation theory; percolation threshold; scaling laws;

D O I：

10.1023/A:1015985521029

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The diffusion of water-soluble solutes in water-soaked porous media was studied by following the release of benzoic acid from poly(vinyl stearate) matrices. The results were analyzed using a pseudo-steady-state diffusion model coupled with the fundamental concepts of percolation theory. The results of the study indicated that the relationship between the bulk diffusion coefficient of benzoic acid in the polymer matrix and the porosity was well described by percolation scaling laws. A very low percolation threshold (0.07) was experimentally observed for this system. © 1990, Plenum Publishing Corporation. All rights reserved.

引用

页码：893 / 901

页数：9

共 39 条

[1] THE ROLE OF POLYMER MATRIX STRUCTURE AND INTERPARTICLE INTERACTIONS IN DIFFUSION-LIMITED DRUG RELEASE [J].