COMPARATIVE EFFECTS OF TETRANDRINE AND BERBAMINE ON PRODUCTION OF THE INFLAMMATORY CYTOKINES INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR

被引：27

作者：

SEOW, WK

FERRANTE, A

SUMMORS, A

THONG, YH

机构：

[1] UNIV QUEENSLAND,MATER CHILDRENS HOSP,DEPT CHILD HLTH,IMMUNOBIOL LAB,BRISBANE 4101,AUSTRALIA

[2] UNIV ADELAIDE,ADELAIDE CHILDRENS HOSP,DEPT PAEDIAT,ADELAIDE 5006,AUSTRALIA

[3] UNIV ADELAIDE,ADELAIDE CHILDRENS HOSP,DEPT IMMUNOL,ADELAIDE 5006,AUSTRALIA

来源：

LIFE SCIENCES | 1992年 / 50卷 / 08期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0024-3205(92)90373-W

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Tetrandrine and berbamine are bisbenzylisoquinoline compounds which differ from each other in a minor way in terms of chemical structure, yet tetrandrine is 6-18 times more potent than berbamine in terms of inhibitory effects on production of interleukin-1 and tumor necrosis factor (TNF-alpha) by monocytes and macrophages, and TNF-beta production by lymphocytes. Moreover, tetrandrine significantly suppressed phosphoinositide turnover while berbamine did not. These findings may provide important insights into structure-activity relationships and the design of novel analogues and congeners useful in the therapy of chronic inflammatory and auto-immune diseases.

引用

页码：PL53 / PL58

页数：6

共 20 条

[1]

CHANG HM, 1987, PHARM APPLICATIONS C

[2]

Chen KK, 1935, J BIOL CHEM, V109, P681

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