MICROTUBULE DESTABILIZATION BY CDC2/H1 HISTONE KINASE - PHOSPHORYLATION OF A PRO-RICH REGION IN THE MICROTUBULE-BINDING DOMAIN OF MAP-4

被引：34

作者：

AIZAWA, H

KAMIJO, M

OHBA, Y

MORI, A

OKUHARA, K

KAWASAKI, H

MUROFUSHI, H

SUZUKI, K

YASUDA, H

机构：

[1] UNIV TOKYO,DIV SCI,DEPT BIOPHYS & BIOCHEM,TOKYO 113,JAPAN

[2] TOKYO METROPOLITAN INST MED SCI,DEPT MOLEC BIOL,TOKYO 113,JAPAN

[3] KANAZAWA UNIV,FAC PHARMACEUT SCI,DEPT BIOL,KANAZAWA,ISHIKAWA 920,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 179卷 / 03期

关键词：

D O I：

10.1016/0006-291X(91)91760-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microtubule-associated protein-4 (MAP-4), a major MAP in proliferating cells, consists of a microtubule-binding domain and a projection domain protruding from the microtubule wall. The former contains a Pro-rich region and an assembly-promoting (AP) sequence region which is common to the neuron-specific MAPs, MAP-2 and tau1. In this paper, we describe the phosphorylation of the Pro-rich region of MAP-4 and the suppression of its assembly-promoting activity by cdc2 H1 histone kinase. This inactivation of MAP-4 may cause disassembly of the interphase microtubular network at the end of the G2 phase of the cell cycle. © 1991.

引用

页码：1620 / 1626

页数：7

共 27 条

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[2]

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