IDENTIFICATION OF A TRANS-ACTING ACTIVITY FROM LIVER THAT STIMULATES HEPATITIS-A VIRUS TRANSLATION INVITRO

被引：40

作者：

GLASS, MJ

SUMMERS, DF

机构：

[1] UNIV CALIF IRVINE, COLL MED, DEPT MICROBIOL & MOLEC GENET, IRVINE, CA 92717 USA

[2] UNIV CALIF IRVINE, COLL MED, DEPT MED, IRVINE, CA 92717 USA

[3] UNIV UTAH, SCH MED, DEPT CELLULAR VIRAL & MOLEC BIOL, SALT LAKE CITY, UT 84132 USA

来源：

VIROLOGY | 1993年 / 193卷 / 02期

关键词：

D O I：

10.1006/viro.1993.1225

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis A virus (HAV), a picornavirus, is the causative agent of infectious hepatitis, generally a self-limiting disease of the liver. Recently, sequences within the 5‘noncoding region that affect the translation of the viral genome have been identified using in vitro systems. In this report we demonstrate that extracts prepared from mouse liver cytoplasm specifically stimulate HAV RNA translation in a rabbit reticulocyte lysate in vitro. This activity appears to act specifically on HAV sequences and is not found in other mouse tissue and several cell lines of tissue culture origin. © 1993 American Health Foundation and Academic Press.

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页码：1047 / 1050

页数：4

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