BIOCHEMICAL-CHARACTERIZATION OF GLUCOSAMINYLMURAMYLDIPEPTIDE BINDING-SITES OF MURINE MACROPHAGES

被引：8

作者：

GOLOVINA, TN

SUMAROKA, MV

SAMOKHVALOVA, LV

SHEBZUKHOV, YV

ANDRONOVA, TM

NESMEYANOV, VA

机构：

[1] Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117871 Moscow

来源：

FEBS LETTERS | 1994年 / 356卷 / 01期

关键词：

MURAMYL PEPTIDE RECEPTOR; AFFINITY LABELING; RADIOLIGAND ANALYSIS;

D O I：

10.1016/0014-5793(94)01219-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By using radioligand analysis, murine peritoneal macrophages were shown to express several hundred high-affinity cell surface GMDP-binding sites (K-a 350 pM). Photoaffinity labeling followed by SDS-PAGE enabled us to identify 32-34 and 38 kDa proteins inside these cells that bound GMDP specifically.

引用

页码：9 / 12

页数：4

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