TIME COURSE OF PAF FORMATION BY GASTROINTESTINAL TISSUE IN RATS AFTER CASTOR-OIL CHALLENGE

被引：38

作者：

PINTO, A ^{[1
]}

AUTORE, G ^{[1
]}

MASCOLO, N ^{[1
]}

SORRENTINO, R ^{[1
]}

BIONDI, A ^{[1
]}

IZZO, AA ^{[1
]}

CAPASSO, F ^{[1
]}

机构：

[1] NAPLES UNIV,DEPT EXPTL PHARMACOL,VIA D MONTESANO 49,I-80131 NAPLES,ITALY

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1992年 / 44卷 / 03期

关键词：

D O I：

10.1111/j.2042-7158.1992.tb03586.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

When castor oil was administered by gavage to rats, the duodenum and jejunum, but not the stomach, produced large amounts of platelet activating factor 3-7 h after oil challenge with a peak at 3 h. Intraluminal release of acid phosphatase was also markedly increased in the duodenum and jejunum of castor oil-treated rats, especially 3-5 h after oil challenge. No increase was observed in the stomach. There was a correlation between elevated release of acid phosphatase and intestinal hyperaemia.

引用

页码：224 / 226

页数：3

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