GLIAL FIBRILLARY ACIDIC PROTEIN MESSENGER-RNA INCREASES AT PROESTRUS IN THE ARCUATE NUCLEUS OF MICE

被引：42

作者：

KOHAMA, SG

GOSS, JR

MCNEILL, TH

FINCH, CE

机构：

[1] UNIV SO CALIF,ETHEL PERCY ANDRUS GERONTOL CTR,LOS ANGELES,CA 90089

[2] UNIV SO CALIF,DEPT BIOL SCI,LOS ANGELES,CA 90089

[3] UNIV PITTSBURGH,MED CTR,DEPT PSYCHIAT,PITTSBURGH,PA 15213

[4] OREGON REG PRIMATE RES CTR,BEAVERTON,OR 97006

来源：

NEUROSCIENCE LETTERS | 1995年 / 183卷 / 03期

关键词：

MICE; GLIAL FIBRILLARY ACIDIC PROTEIN; IN SITU HYBRIDIZATION; ARCUATE NUCLEUS; ESTROUS CYCLE;

D O I：

10.1016/0304-3940(94)11141-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glial fibrillary acidic protein (GFAP) increases during proestrus in astrocytes of the hypothalamic arcuate nucleus (ARC). These changes are associated with altered astrocyte-neuron contacts and synaptic remodelling, during preparation for the preovulatory gonadotrophin surge. This study of young C57BL/6J mice showed transient elevations of GFAP mRNA on proestrus in the ARC by in situ hybridization. Basal GFAP mRNA was regained within 18 h. We hypothesize that changes in astrocytic GFAP on proestrus result from elevations of GFAP mRNA that are, in turn, driven by ovarian secretions of estradiol.

引用

页码：164 / 166

页数：3

共 25 条

[1] STRUCTURE AND TRANSCRIPTIONAL REGULATION OF THE GFAP GENE [J].