A NEW PHLOROGLUCINOL DERIVATIVE FROM HYPERICUM-CALYCINUM WITH ANTIFUNGAL AND INVITRO ANTIMALARIAL ACTIVITY

被引：53

作者：

DECOSTERD, LA

HOFFMANN, E

KYBURZ, R

BRAY, D

HOSTETTMANN, K

机构：

[1] UNIV LAUSANNE, ECOLE PHARM, INST PHARMACOGNOSIE & PHYTOCHIM, CH-1015 LAUSANNE, SWITZERLAND

[2] VARIAN GMBH, NMR APPLICAT LAB, W-6100 DARMSTADT, GERMANY

[3] ROYAL FREE HOSP MED, DEPT IMMUNOL, LONDON NW3 2Q6, ENGLAND

来源：

PLANTA MEDICA | 1991年 / 57卷 / 06期

关键词：

HYPERICUM-CALYCINUM; CLADOSPORIUM-CUCUMERINUM; PHLOROGLUCINOL DERIVATIVE; ANTIFUNGAL ACTIVITY; ANTIMALARIAL ACTIVITY; PLASMODIUM-FALCIPARUM;

D O I：

10.1055/s-2006-960203

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The new phloroglucinol derivative 1 has been isolated from the light petroleum ether extract of the aerial parts of Hypericum calycinum. Its structure has been established by means of H-1-and C-13-NMR spectroscopy and by nOe, MHQC, and HMBC experiments on its monomethyl ether derivative 3. Compound 1 was fungicidal against Cladosporium cucumerinum in a TLC bioassay. In addition, this new phloroglucinol derivative was also found to exert an interesting antimalarial activity in an in vitro test system.

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页码：548 / 551

页数：4

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