EXPRESSION OF SIMPLE EPITHELIAL KERATIN-8 AND KERATIN-18 IN EPIDERMAL NEOPLASIA

被引：105

作者：

MARKEY, AC

LANE, EB

CHURCHILL, LJ

MACDONALD, DM

LEIGH, IM

机构：

[1] LONDON HOSP,COLL MED,IMPERIAL CANC RES FUND,SKIN TUMOUR LAB,56 ASHFIELD ST,LONDON E1 2BL,ENGLAND

[2] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,APPL DERMATOPATHOL LAB,LONDON,ENGLAND

[3] UNIV DUNDEE,CRC,DEPT BIOCHEM,CELL STRUCT RES GRP,DUNDEE DD1 4HN,SCOTLAND

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1991年 / 97卷 / 05期

关键词：

D O I：

10.1111/1523-1747.ep12486607

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A systematic study of keratin expression in epidermal lesions (six actinic keratoses, 10 Bowen's disease, seven squamous cell carcinomas) has been undertaken by using a large panel of monospecific monoclonal antibodies to individual keratins. Expression of differentiation-specific keratins was frequently delayed or lost from dysplastic regions. Novel expression of the embryonic, or simple epithelial, keratins 8 and 18 was widely observed in intradermal areas of poorly differentiated squamous cell carcinomas. In addition, the most proliferative of in situ malignancies (Bowen's disease) also contained small numbers of cells expressing simple epithelial keratins. These observations suggest that the expression of simple epithelial keratins may be of functional importance in malignancy of keratinocytes and could be related to tumor invasion and/or to changes in epithelial-mesenchymal interactions.

引用

页码：763 / 770

页数：8

共 68 条

[1] CYTOKERATINS IN CERVICAL DYSPLASIA AND NEOPLASIA - A COMPARATIVE-STUDY OF IMMUNOHISTOCHEMICAL STAINING USING MONOCLONAL-ANTIBODIES NCL-5D3, CAM 5.2, AND PKK1 [J].