SYNTHESES AND RADIOPROTECTIVE ACTIVITIES OF TRITHIAGERMATRANES, TRITHIASILATRANES, GERMYLATED OXIDE AND SULFIDE WITH CYSTEAMINE AND N-(2-THIOETHYL)-1,3-DIAMINOPROPANE CHLORHYDRATE LIGANDS

被引：13

作者：

RIMA, G

SATGE, J

FATOME, M

LAVAL, JD

SENTENACROUMANOU, H

LION, C

LAZRAQ, M

机构：

[1] SERV SANTE ARMEES GRENOBLE,CTR RECH,UNITE RADIOPROTECT,F-38702 LA TRONCHE,FRANCE

[2] DIRECT RECH ETUD & TECH,F-00460 ARMEES,FRANCE

[3] UNIV PARIS 07,INST TOPOL & DYNAM SYST,CNRS,F-75221 PARIS 05,FRANCE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 26卷 / 03期

关键词：

TRITHIAGERMATRANES; TRITHIASILATRANES; BICYCLODITHIAZAGERMOLIDINES; RADIOPROTECTIVE ACTIVITY;

D O I：

10.1016/0223-5234(91)90061-Q

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New organotrithiagermatranes, trithiasilatranes, bicyclodithiazagermolidines and 6-aza-1,3-dithia 2-germaperhydrocine with cysteamine and N-(2-thioethyl)-1,3-diaminopropane chlorhydrate ligands and germylated oxide and sulfide with N-(2-thioethyl)-1,3-diaminopropane chlorhydrate ligands were synthesized. Their toxicities and radioprotective activities were determined.

引用

页码：291 / 297

页数：7

共 14 条

[1]

GAR TK, 1982, BIOL ACTIVITIES GERM

[2]

KHROMOVA NY, 1985, HETEROOIRGANIC COMPO

[3] CHEMICAL PROTECTION AGAINST IONIZING RADIATION .1. SAMPLING METHODS FOR SCREENING COMPOUNDS IN RADIATION PROTECTION STUDIES WITH MICE [J].