AN EFFICIENT ALGORITHM TO COMPUTE THE POSTERIOR GENOTYPIC DISTRIBUTION FOR EVERY MEMBER OF A PEDIGREE WITHOUT LOOPS

被引：41

作者：

FERNANDO, RL ^{[1
]}

STRICKER, C ^{[1
]}

ELSTON, RC ^{[1
]}

机构：

[1] LOUISIANA STATE UNIV,MED CTR,DEPT BIOMETRY & GENET,NEW ORLEANS,LA 70112

来源：

THEORETICAL AND APPLIED GENETICS | 1993年 / 87卷 / 1-2期

关键词：

GENOTYPE PROBABILITIES; LIKELIHOOD; RECURSIVE ALGORITHM;

D O I：

10.1007/BF00223750

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

This paper describes a non-iterative, recursive method to compute the likelihood for a pedigree without loops, and hence an efficient way to compute genotype probabilities for every member of the pedigree. The method can be used with multiple mates and large sib-ships. Scaling is used in calculations to avoid numerical problems in working with large pedigrees.

引用

页码：89 / 93

页数：5

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