A DOSE-RESPONSE STUDY OF THE EFFECTS OF INTRAVENOUS MIDAZOLAM ON COLD PRESSER-INDUCED PAIN

被引：25

作者：

ZACNY, JP ^{[1
]}

COALSON, D ^{[1
]}

YOUNG, C ^{[1
]}

KLAFTA, J ^{[1
]}

RUPANI, G ^{[1
]}

THAPAR, P ^{[1
]}

CHOI, M ^{[1
]}

APFELBAUM, JL ^{[1
]}

机构：

[1] UNIV CHICAGO,DEPT PSYCHIAT,CHICAGO,IL 60637

来源：

ANESTHESIA AND ANALGESIA | 1995年 / 80卷 / 03期

关键词：

D O I：

10.1097/00000539-199503000-00015

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The effects of intravenous midazolam (0.75, 1.5, and 3 mg/70 kg) were examined and compared to that of fentanyl (0.1 mg/70 kg; positive control) and saline on pain induced by a cold presser test. Both sensory and affective components of the pain response were assessed, as there is some evidence that benzodiazepines reduce the affective component. Healthy volunteers (three females, nine males) were enrolled in a prospective, double-blind, randomized, cross-over trial in which mood and psychomotor performance were also examined. Five minutes and 135 min postinjection, subjects immersed their forearm in ice-cold water for 3 min while assessments of pain were recorded. During the first immersion, subjects reported significantly lower pain intensity and bothersomeness ratings after having been injected with fentanyl, relative to the saline and midazolam conditions, which did not differ significantly from each other. Fentanyl and midazolam had prototypical mood altering and psychomotor impairing effects. We conclude that midazolam in our laboratory setting at the doses and route of administration studied had no effects on either the sensory or affective components of the pain experience.

引用

页码：521 / 525

页数：5

共 24 条

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[2]

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